Standard
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. / Nielsen, Lars Bo; Ploug, K.B.; Swift, P.; Ørskov, Anne Cathrine; Jansen-Olesen, I.; Chiarelli, F.; Holst, J.J.; Hougaard, Poul Philip; Porksen, S.; Holl, R.; Beaufort, C. de; Gammeltoft, S.; Rorsman, P.; Mortensen, Henrik B.; Hansen, L.; Nielsen, Lotte B; Ploug, Kenneth B; Swift, Peter; Ørskov, Cathrine; Jansen-Olesen, Inger; Chiarelli, Francesco; Holst, Jens Juul; Hougaard, Philip; Pörksen, Sven; Holl, Reinhard; de Beaufort, Carine; Gammeltoft, Steen; Rorsman, Patrik; Mortensen, Henrik B; Hansen, Lars; Hvidøre Study Group.
In:
European Journal of Endocrinology, Vol. 156, No. 6, 2007, p. 663-71.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Nielsen, LB, Ploug, KB, Swift, P
, Ørskov, AC, Jansen-Olesen, I, Chiarelli, F
, Holst, JJ, Hougaard, PP, Porksen, S, Holl, R, Beaufort, CD, Gammeltoft, S, Rorsman, P, Mortensen, HB, Hansen, L, Nielsen, LB, Ploug, KB, Swift, P, Ørskov, C, Jansen-Olesen, I, Chiarelli, F, Holst, JJ, Hougaard, P, Pörksen, S, Holl, R, de Beaufort, C, Gammeltoft, S, Rorsman, P, Mortensen, HB, Hansen, L & Hvidøre Study Group 2007, '
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes',
European Journal of Endocrinology, vol. 156, no. 6, pp. 663-71.
https://doi.org/10.1530/EJE-06-0756APA
Nielsen, L. B., Ploug, K. B., Swift, P.
, Ørskov, A. C., Jansen-Olesen, I., Chiarelli, F.
, Holst, J. J., Hougaard, P. P., Porksen, S., Holl, R., Beaufort, C. D., Gammeltoft, S., Rorsman, P., Mortensen, H. B., Hansen, L., Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, C., ... Hvidøre Study Group (2007).
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
European Journal of Endocrinology,
156(6), 663-71.
https://doi.org/10.1530/EJE-06-0756Vancouver
Nielsen LB, Ploug KB, Swift P
, Ørskov AC, Jansen-Olesen I, Chiarelli F et al.
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
European Journal of Endocrinology. 2007;156(6):663-71.
https://doi.org/10.1530/EJE-06-0756Author
Nielsen, Lars Bo ; Ploug, K.B. ; Swift, P. ; Ørskov, Anne Cathrine ; Jansen-Olesen, I. ; Chiarelli, F. ; Holst, J.J. ; Hougaard, Poul Philip ; Porksen, S. ; Holl, R. ; Beaufort, C. de ; Gammeltoft, S. ; Rorsman, P. ; Mortensen, Henrik B. ; Hansen, L. ; Nielsen, Lotte B ; Ploug, Kenneth B ; Swift, Peter ; Ørskov, Cathrine ; Jansen-Olesen, Inger ; Chiarelli, Francesco ; Holst, Jens Juul ; Hougaard, Philip ; Pörksen, Sven ; Holl, Reinhard ; de Beaufort, Carine ; Gammeltoft, Steen ; Rorsman, Patrik ; Mortensen, Henrik B ; Hansen, Lars ; Hvidøre Study Group. / Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. In: European Journal of Endocrinology. 2007 ; Vol. 156, No. 6. pp. 663-71.
Bibtex
@article{43db022020ec11ddbc23000ea68e967b,
title = "Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes",
abstract = "The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.",
author = "Nielsen, {Lars Bo} and K.B. Ploug and P. Swift and {\O}rskov, {Anne Cathrine} and I. Jansen-Olesen and F. Chiarelli and J.J. Holst and Hougaard, {Poul Philip} and S. Porksen and R. Holl and Beaufort, {C. de} and S. Gammeltoft and P. Rorsman and Mortensen, {Henrik B.} and L. Hansen and Nielsen, {Lotte B} and Ploug, {Kenneth B} and Peter Swift and Cathrine {\O}rskov and Inger Jansen-Olesen and Francesco Chiarelli and Holst, {Jens Juul} and Philip Hougaard and Sven P{\"o}rksen and Reinhard Holl and {de Beaufort}, Carine and Steen Gammeltoft and Patrik Rorsman and Mortensen, {Henrik B} and Lars Hansen and Mortensen, {Henrik B.}",
year = "2007",
doi = "http://dx.doi.org/10.1530/EJE-06-0756",
language = "English",
volume = "156",
pages = "663--71",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "6",
}
RIS
TY - JOUR
T1 - Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
AU - Nielsen, Lars Bo
AU - Ploug, K.B.
AU - Swift, P.
AU - Ørskov, Anne Cathrine
AU - Jansen-Olesen, I.
AU - Chiarelli, F.
AU - Holst, J.J.
AU - Hougaard, Poul Philip
AU - Porksen, S.
AU - Holl, R.
AU - Beaufort, C. de
AU - Gammeltoft, S.
AU - Rorsman, P.
AU - Mortensen, Henrik B.
AU - Hansen, L.
AU - Nielsen, Lotte B
AU - Ploug, Kenneth B
AU - Swift, Peter
AU - Ørskov, Cathrine
AU - Jansen-Olesen, Inger
AU - Chiarelli, Francesco
AU - Holst, Jens Juul
AU - Hougaard, Philip
AU - Pörksen, Sven
AU - Holl, Reinhard
AU - de Beaufort, Carine
AU - Gammeltoft, Steen
AU - Rorsman, Patrik
AU - Mortensen, Henrik B
AU - Hansen, Lars
AU - Hvidøre Study Group
PY - 2007
Y1 - 2007
N2 - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
AB - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
U2 - http://dx.doi.org/10.1530/EJE-06-0756
DO - http://dx.doi.org/10.1530/EJE-06-0756
M3 - Journal article
VL - 156
SP - 663
EP - 671
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -
