Dissociated incretin hormone response to protein versus fat ingestion in obese subjects
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Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. / Lindgren, O; Carr, RD; Holst, Jens Juul; Deacon, Carolyn F.; Ahren, B.
In: Diabetes, Obesity and Metabolism Online, Vol. 13, No. 9, 07.2011, p. 863-865.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dissociated incretin hormone response to protein versus fat ingestion in obese subjects
AU - Lindgren, O
AU - Carr, RD
AU - Holst, Jens Juul
AU - Deacon, Carolyn F.
AU - Ahren, B
N1 - © 2011 Blackwell Publishing Ltd.
PY - 2011/7
Y1 - 2011/7
N2 - Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.
AB - Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.
KW - Adult
KW - Dietary Fats
KW - Dietary Proteins
KW - Gastric Inhibitory Polypeptide
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Incretins
KW - Male
KW - Obesity
U2 - 10.1111/j.1463-1326.2011.01420.x
DO - 10.1111/j.1463-1326.2011.01420.x
M3 - Journal article
C2 - 21554523
VL - 13
SP - 863
EP - 865
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 9
ER -
ID: 38186440