IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats
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IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats. / Thomsen, Karen; Aagaard, Niels Kristian; Grønbæk, Henning; Holst, Jens Juul; Jessen, Niels; Frystyk, Jan; Vilstrup, Hendrik.
In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 71, No. 2, 04.2011, p. 150-156.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats
AU - Thomsen, Karen
AU - Aagaard, Niels Kristian
AU - Grønbæk, Henning
AU - Holst, Jens Juul
AU - Jessen, Niels
AU - Frystyk, Jan
AU - Vilstrup, Hendrik
PY - 2011/4
Y1 - 2011/4
N2 - Clinical or experimentally induced, active inflammation up-regulates the in vivo capacity of urea synthesis (CUNS), which promotes nitrogen removal from the body and metabolic catabolism. We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration. The described effect of TNF-a on nitrogen homeostasis may, therefore, depend on IL-6.
AB - Clinical or experimentally induced, active inflammation up-regulates the in vivo capacity of urea synthesis (CUNS), which promotes nitrogen removal from the body and metabolic catabolism. We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration. The described effect of TNF-a on nitrogen homeostasis may, therefore, depend on IL-6.
KW - Acute-Phase Proteins
KW - Animals
KW - Blood Glucose
KW - Corticosterone
KW - Female
KW - Gene Expression Regulation
KW - Glucagon
KW - Humans
KW - Insulin
KW - Interleukin-6
KW - Liver
KW - RNA, Messenger
KW - Rats
KW - Rats, Wistar
KW - Somatomedins
KW - Urea
U2 - 10.3109/00365513.2010.547213
DO - 10.3109/00365513.2010.547213
M3 - Journal article
C2 - 21190512
VL - 71
SP - 150
EP - 156
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 2
ER -
ID: 38531833