Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans
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Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. / Lindgren, Ola; Carr, Richard D; Deacon, Carolyn F; Holst, Jens Juul; Pacini, Giovanni; Mari, Andrea; Ahrén, Bo.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 08.2011, p. 2519-2524.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans
AU - Lindgren, Ola
AU - Carr, Richard D
AU - Deacon, Carolyn F
AU - Holst, Jens Juul
AU - Pacini, Giovanni
AU - Mari, Andrea
AU - Ahrén, Bo
PY - 2011/8
Y1 - 2011/8
N2 - Context: The incretin effect is responsible for the higher insulin response to oral glucose than to iv glucose at matching glucose levels. It is notknownwhetherthis effect is restricted to glucose only. Objective: The aim of the study was to examine whether insulin and incretin hormone responses are higher after oral vs. iv challenge of a lipid emulsion with matching triglyceride levels in humans. Design, Settings, and Participants: A lipid emulsion (Intralipid) was administered orally (3 ml/kg) or iv (variable infusion rates to match triglyceride levels after oral ingestion) in healthy lean males (n 12) at a University Clinical Research Unit. Samples were collected during 300 min. Main Outcome Measures:Wemeasured the suprabasal area under the curve for insulin, glucagonlike peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the insulin secretory rate based on C-peptide levels by deconvolution. Results: Triglyceride levels increased similarly after oral and iv lipid; also, glucose and free fatty acid levels were similar in the two tests. Oral lipid elicited a clear insulin and C-peptide response, whereas no insulin or C-peptide responses were observed during iv lipid. Total and intact GIP and GLP-1 levels both increased after oral lipid administration but were not significantly altered after iv lipid. Conclusions: At matching triglyceride levels and with no difference in glucose and free fatty acid levels, oral lipid ingestion but not iv lipid infusion elicits a clear insulin response in association with increased GIP and GLP-1 concentrations. This may suggest that the incretin hormones also contribute to the islet response to noncarbohydrate nutrients.
AB - Context: The incretin effect is responsible for the higher insulin response to oral glucose than to iv glucose at matching glucose levels. It is notknownwhetherthis effect is restricted to glucose only. Objective: The aim of the study was to examine whether insulin and incretin hormone responses are higher after oral vs. iv challenge of a lipid emulsion with matching triglyceride levels in humans. Design, Settings, and Participants: A lipid emulsion (Intralipid) was administered orally (3 ml/kg) or iv (variable infusion rates to match triglyceride levels after oral ingestion) in healthy lean males (n 12) at a University Clinical Research Unit. Samples were collected during 300 min. Main Outcome Measures:Wemeasured the suprabasal area under the curve for insulin, glucagonlike peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the insulin secretory rate based on C-peptide levels by deconvolution. Results: Triglyceride levels increased similarly after oral and iv lipid; also, glucose and free fatty acid levels were similar in the two tests. Oral lipid elicited a clear insulin and C-peptide response, whereas no insulin or C-peptide responses were observed during iv lipid. Total and intact GIP and GLP-1 levels both increased after oral lipid administration but were not significantly altered after iv lipid. Conclusions: At matching triglyceride levels and with no difference in glucose and free fatty acid levels, oral lipid ingestion but not iv lipid infusion elicits a clear insulin response in association with increased GIP and GLP-1 concentrations. This may suggest that the incretin hormones also contribute to the islet response to noncarbohydrate nutrients.
KW - Administration, Oral
KW - Adult
KW - Area Under Curve
KW - Blood Glucose
KW - C-Peptide
KW - Emulsions
KW - Fatty Acids, Nonesterified
KW - Gastric Inhibitory Polypeptide
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Incretins
KW - Infusions, Intravenous
KW - Insulin
KW - Male
KW - Phospholipids
KW - Soybean Oil
KW - Triglycerides
KW - Young Adult
U2 - 10.1210/jc.2011-0266
DO - 10.1210/jc.2011-0266
M3 - Journal article
C2 - 21593115
VL - 96
SP - 2519
EP - 2524
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 8
ER -
ID: 38186559