No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery
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No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery. / Dirksen, Carsten; Eiken, Aleksander; Bojsen-Møller, Kirstine N; Svane, Maria S; Martinussen, Christoffer; Jørgensen, Nils B; Holst, Jens J; Madsbad, Sten.
In: Obesity Surgery, Vol. 26, No. 9, 09.2016, p. 2263-7.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery
AU - Dirksen, Carsten
AU - Eiken, Aleksander
AU - Bojsen-Møller, Kirstine N
AU - Svane, Maria S
AU - Martinussen, Christoffer
AU - Jørgensen, Nils B
AU - Holst, Jens J
AU - Madsbad, Sten
PY - 2016/9
Y1 - 2016/9
N2 - Postprandial hyperinsulinemia characterizes Roux-en-Y gastric bypass (RYGB) and sometimes leads to reactive hypoglycemia. We prospectively evaluated changes in beta cell function in seven RYGB-operated patients with a median follow-up of 2.9 years with hyperglycemic clamps and oral glucose tolerance tests (OGTTs). Three years after RYGB, weight loss was 26 % and insulin sensitivity had improved. Insulin secretion during clamp experiments was largely unchanged compared to before surgery. In contrast, insulin secretion in response to the OGTTs doubled when evaluated by the disposition index and 2-h plasma glucose declined to a mean of 3.3 ± 0.3 mmol/l postoperatively. Our findings indicate that intrinsic beta cell function remains unchanged in glucose-tolerant patients even years after RYGB, while altered gut-islet regulation drive risk of postprandial hyperinsulinemic hypoglycemia.
AB - Postprandial hyperinsulinemia characterizes Roux-en-Y gastric bypass (RYGB) and sometimes leads to reactive hypoglycemia. We prospectively evaluated changes in beta cell function in seven RYGB-operated patients with a median follow-up of 2.9 years with hyperglycemic clamps and oral glucose tolerance tests (OGTTs). Three years after RYGB, weight loss was 26 % and insulin sensitivity had improved. Insulin secretion during clamp experiments was largely unchanged compared to before surgery. In contrast, insulin secretion in response to the OGTTs doubled when evaluated by the disposition index and 2-h plasma glucose declined to a mean of 3.3 ± 0.3 mmol/l postoperatively. Our findings indicate that intrinsic beta cell function remains unchanged in glucose-tolerant patients even years after RYGB, while altered gut-islet regulation drive risk of postprandial hyperinsulinemic hypoglycemia.
KW - Journal Article
U2 - 10.1007/s11695-016-2197-x
DO - 10.1007/s11695-016-2197-x
M3 - Letter
C2 - 27138601
VL - 26
SP - 2263
EP - 2267
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 9
ER -
ID: 165938991