The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat

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Standard

The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat. / Poulsen, Steen Seier; Holst, J J.

In: Digestion, Vol. 40, No. 3, 1988, p. 144-51.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Holst, JJ 1988, 'The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat', Digestion, vol. 40, no. 3, pp. 144-51.

APA

Poulsen, S. S., & Holst, J. J. (1988). The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat. Digestion, 40(3), 144-51.

Vancouver

Poulsen SS, Holst JJ. The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat. Digestion. 1988;40(3):144-51.

Author

Poulsen, Steen Seier ; Holst, J J. / The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat. In: Digestion. 1988 ; Vol. 40, No. 3. pp. 144-51.

Bibtex

@article{dd427638edf044a5ba31e9ecbf44f8c1,
title = "The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat",
abstract = "Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [14C]-aminopyrine accumulation, a reliable index of H+ generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine-stimulated gastric acid secretion. Electron-microscopic studies of unstimulated and histamine-stimulated parietal cells confirmed that the cells retained the normal morphology of intracellular organelles and that the cells responded to physiological stimulation by marked expansion of the intracellular canaliculi.",
keywords = "Aminopyrine, Animals, Gastric Acid, Gastrin-Releasing Peptide, Gastrins, Gastrointestinal Hormones, Glicentin, Glucagon, Glucagon-Like Peptides, Histamine, Microscopy, Electron, Oxyntomodulin, Parietal Cells, Gastric, Peptide Fragments, Peptides, Protein Precursors, Rats",
author = "Poulsen, {Steen Seier} and Holst, {J J}",
year = "1988",
language = "English",
volume = "40",
pages = "144--51",
journal = "Digestion",
issn = "0012-2823",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat

AU - Poulsen, Steen Seier

AU - Holst, J J

PY - 1988

Y1 - 1988

N2 - Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [14C]-aminopyrine accumulation, a reliable index of H+ generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine-stimulated gastric acid secretion. Electron-microscopic studies of unstimulated and histamine-stimulated parietal cells confirmed that the cells retained the normal morphology of intracellular organelles and that the cells responded to physiological stimulation by marked expansion of the intracellular canaliculi.

AB - Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [14C]-aminopyrine accumulation, a reliable index of H+ generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine-stimulated gastric acid secretion. Electron-microscopic studies of unstimulated and histamine-stimulated parietal cells confirmed that the cells retained the normal morphology of intracellular organelles and that the cells responded to physiological stimulation by marked expansion of the intracellular canaliculi.

KW - Aminopyrine

KW - Animals

KW - Gastric Acid

KW - Gastrin-Releasing Peptide

KW - Gastrins

KW - Gastrointestinal Hormones

KW - Glicentin

KW - Glucagon

KW - Glucagon-Like Peptides

KW - Histamine

KW - Microscopy, Electron

KW - Oxyntomodulin

KW - Parietal Cells, Gastric

KW - Peptide Fragments

KW - Peptides

KW - Protein Precursors

KW - Rats

M3 - Journal article

C2 - 3234620

VL - 40

SP - 144

EP - 151

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 3

ER -

ID: 47488400