Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. / Randall, Joshua C; Winkler, Thomas W; Kutalik, Zoltán; Berndt, Sonja I; Jackson, Anne U; Monda, Keri L; Oskari Kilpeläinen, Tuomas; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; Feitosa, Mary F; Croteau-Chonka, Damien C; Day, Felix R; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Locke, Adam E; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; Wood, Andrew R; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Dermitzakis, Emmanouil T; Dimas, Antigone S; Karpe, Fredrik; Min, Josine L; Nicholson, George; Clegg, Deborah J; Person, Thomas; Krohn, Jon P; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Hottenga, Jouke-Jan; Prokopenko, Inga; Waite, Lindsay L; Harris, Tamara B; Smith, Albert Vernon; Shuldiner, Alan R; McArdle, Wendy L; Caulfield, Mark J; Kovacs, Peter; Schwarz, Peter E H; Lind, Lars; Njølstad, Inger; DIAGRAM Consortium.

In: P L o S Genetics, Vol. 9, No. 6, e1003500, 06.2013, p. 1-19.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Randall, JC, Winkler, TW, Kutalik, Z, Berndt, SI, Jackson, AU, Monda, KL, Oskari Kilpeläinen, T, Esko, T, Mägi, R, Li, S, Workalemahu, T, Feitosa, MF, Croteau-Chonka, DC, Day, FR, Fall, T, Ferreira, T, Gustafsson, S, Locke, AE, Mathieson, I, Scherag, A, Vedantam, S, Wood, AR, Liang, L, Steinthorsdottir, V, Thorleifsson, G, Dermitzakis, ET, Dimas, AS, Karpe, F, Min, JL, Nicholson, G, Clegg, DJ, Person, T, Krohn, JP, Bauer, S, Buechler, C, Eisinger, K, Bonnefond, A, Froguel, P, Hottenga, J-J, Prokopenko, I, Waite, LL, Harris, TB, Smith, AV, Shuldiner, AR, McArdle, WL, Caulfield, MJ, Kovacs, P, Schwarz, PEH, Lind, L, Njølstad, I & DIAGRAM Consortium 2013, 'Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits', P L o S Genetics, vol. 9, no. 6, e1003500, pp. 1-19. https://doi.org/10.1371/journal.pgen.1003500

APA

Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Oskari Kilpeläinen, T., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., ... DIAGRAM Consortium (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. P L o S Genetics, 9(6), 1-19. [e1003500]. https://doi.org/10.1371/journal.pgen.1003500

Vancouver

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL et al. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. P L o S Genetics. 2013 Jun;9(6):1-19. e1003500. https://doi.org/10.1371/journal.pgen.1003500

Author

Randall, Joshua C ; Winkler, Thomas W ; Kutalik, Zoltán ; Berndt, Sonja I ; Jackson, Anne U ; Monda, Keri L ; Oskari Kilpeläinen, Tuomas ; Esko, Tõnu ; Mägi, Reedik ; Li, Shengxu ; Workalemahu, Tsegaselassie ; Feitosa, Mary F ; Croteau-Chonka, Damien C ; Day, Felix R ; Fall, Tove ; Ferreira, Teresa ; Gustafsson, Stefan ; Locke, Adam E ; Mathieson, Iain ; Scherag, Andre ; Vedantam, Sailaja ; Wood, Andrew R ; Liang, Liming ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Dermitzakis, Emmanouil T ; Dimas, Antigone S ; Karpe, Fredrik ; Min, Josine L ; Nicholson, George ; Clegg, Deborah J ; Person, Thomas ; Krohn, Jon P ; Bauer, Sabrina ; Buechler, Christa ; Eisinger, Kristina ; Bonnefond, Amélie ; Froguel, Philippe ; Hottenga, Jouke-Jan ; Prokopenko, Inga ; Waite, Lindsay L ; Harris, Tamara B ; Smith, Albert Vernon ; Shuldiner, Alan R ; McArdle, Wendy L ; Caulfield, Mark J ; Kovacs, Peter ; Schwarz, Peter E H ; Lind, Lars ; Njølstad, Inger ; DIAGRAM Consortium. / Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. In: P L o S Genetics. 2013 ; Vol. 9, No. 6. pp. 1-19.

Bibtex

@article{ea79063421d7423aba43197c6cb11cfe,
title = "Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits",
abstract = "Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR",
author = "Randall, {Joshua C} and Winkler, {Thomas W} and Zolt{\'a}n Kutalik and Berndt, {Sonja I} and Jackson, {Anne U} and Monda, {Keri L} and {Oskari Kilpel{\"a}inen}, Tuomas and T{\~o}nu Esko and Reedik M{\"a}gi and Shengxu Li and Tsegaselassie Workalemahu and Feitosa, {Mary F} and Croteau-Chonka, {Damien C} and Day, {Felix R} and Tove Fall and Teresa Ferreira and Stefan Gustafsson and Locke, {Adam E} and Iain Mathieson and Andre Scherag and Sailaja Vedantam and Wood, {Andrew R} and Liming Liang and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Dermitzakis, {Emmanouil T} and Dimas, {Antigone S} and Fredrik Karpe and Min, {Josine L} and George Nicholson and Clegg, {Deborah J} and Thomas Person and Krohn, {Jon P} and Sabrina Bauer and Christa Buechler and Kristina Eisinger and Am{\'e}lie Bonnefond and Philippe Froguel and Jouke-Jan Hottenga and Inga Prokopenko and Waite, {Lindsay L} and Harris, {Tamara B} and Smith, {Albert Vernon} and Shuldiner, {Alan R} and McArdle, {Wendy L} and Caulfield, {Mark J} and Peter Kovacs and Schwarz, {Peter E H} and Lars Lind and Inger Nj{\o}lstad and {DIAGRAM Consortium}",
year = "2013",
month = jun,
doi = "10.1371/journal.pgen.1003500",
language = "English",
volume = "9",
pages = "1--19",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "6",

}

RIS

TY - JOUR

T1 - Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

AU - Randall, Joshua C

AU - Winkler, Thomas W

AU - Kutalik, Zoltán

AU - Berndt, Sonja I

AU - Jackson, Anne U

AU - Monda, Keri L

AU - Oskari Kilpeläinen, Tuomas

AU - Esko, Tõnu

AU - Mägi, Reedik

AU - Li, Shengxu

AU - Workalemahu, Tsegaselassie

AU - Feitosa, Mary F

AU - Croteau-Chonka, Damien C

AU - Day, Felix R

AU - Fall, Tove

AU - Ferreira, Teresa

AU - Gustafsson, Stefan

AU - Locke, Adam E

AU - Mathieson, Iain

AU - Scherag, Andre

AU - Vedantam, Sailaja

AU - Wood, Andrew R

AU - Liang, Liming

AU - Steinthorsdottir, Valgerdur

AU - Thorleifsson, Gudmar

AU - Dermitzakis, Emmanouil T

AU - Dimas, Antigone S

AU - Karpe, Fredrik

AU - Min, Josine L

AU - Nicholson, George

AU - Clegg, Deborah J

AU - Person, Thomas

AU - Krohn, Jon P

AU - Bauer, Sabrina

AU - Buechler, Christa

AU - Eisinger, Kristina

AU - Bonnefond, Amélie

AU - Froguel, Philippe

AU - Hottenga, Jouke-Jan

AU - Prokopenko, Inga

AU - Waite, Lindsay L

AU - Harris, Tamara B

AU - Smith, Albert Vernon

AU - Shuldiner, Alan R

AU - McArdle, Wendy L

AU - Caulfield, Mark J

AU - Kovacs, Peter

AU - Schwarz, Peter E H

AU - Lind, Lars

AU - Njølstad, Inger

AU - DIAGRAM Consortium

PY - 2013/6

Y1 - 2013/6

N2 - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

AB - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

U2 - 10.1371/journal.pgen.1003500

DO - 10.1371/journal.pgen.1003500

M3 - Journal article

C2 - 23754948

VL - 9

SP - 1

EP - 19

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

IS - 6

M1 - e1003500

ER -

ID: 46279463