The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study

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The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. / Oskari Kilpeläinen, Tuomas; Laaksonen, D E; Lakka, T A; Herder, C; Koenig, W; Lindström, J; Eriksson, J G; Uusitupa, M; Kolb, H; Laakso, M; Tuomilehto, J; Finnish Diabetes Prevention Study.

In: Experimental and Clinical Endocrinology and Diabetes, Vol. 118, No. 10, 11.2010, p. 757-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Oskari Kilpeläinen, T, Laaksonen, DE, Lakka, TA, Herder, C, Koenig, W, Lindström, J, Eriksson, JG, Uusitupa, M, Kolb, H, Laakso, M, Tuomilehto, J & Finnish Diabetes Prevention Study 2010, 'The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study', Experimental and Clinical Endocrinology and Diabetes, vol. 118, no. 10, pp. 757-9. https://doi.org/10.1055/s-0030-1249686

APA

Oskari Kilpeläinen, T., Laaksonen, D. E., Lakka, T. A., Herder, C., Koenig, W., Lindström, J., Eriksson, J. G., Uusitupa, M., Kolb, H., Laakso, M., Tuomilehto, J., & Finnish Diabetes Prevention Study (2010). The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. Experimental and Clinical Endocrinology and Diabetes, 118(10), 757-9. https://doi.org/10.1055/s-0030-1249686

Vancouver

Oskari Kilpeläinen T, Laaksonen DE, Lakka TA, Herder C, Koenig W, Lindström J et al. The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. Experimental and Clinical Endocrinology and Diabetes. 2010 Nov;118(10):757-9. https://doi.org/10.1055/s-0030-1249686

Author

Oskari Kilpeläinen, Tuomas ; Laaksonen, D E ; Lakka, T A ; Herder, C ; Koenig, W ; Lindström, J ; Eriksson, J G ; Uusitupa, M ; Kolb, H ; Laakso, M ; Tuomilehto, J ; Finnish Diabetes Prevention Study. / The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. In: Experimental and Clinical Endocrinology and Diabetes. 2010 ; Vol. 118, No. 10. pp. 757-9.

Bibtex

@article{d5fe850f2c9a4190b8dc18bf05e537f3,
title = "The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study",
abstract = "Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor ( TNF) gene and the rs1800795 SNP in the interleukin-6 ( IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels ( P = 0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL-6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.",
keywords = "C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Finland, Genetic Association Studies, Glucose Intolerance, Humans, Interleukin-6, Male, Motor Activity, Overweight, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Time Factors, Tumor Necrosis Factor-alpha",
author = "{Oskari Kilpel{\"a}inen}, Tuomas and Laaksonen, {D E} and Lakka, {T A} and C Herder and W Koenig and J Lindstr{\"o}m and Eriksson, {J G} and M Uusitupa and H Kolb and M Laakso and J Tuomilehto and {Finnish Diabetes Prevention Study}",
note = "{\textcopyright} J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.",
year = "2010",
month = nov,
doi = "10.1055/s-0030-1249686",
language = "English",
volume = "118",
pages = "757--9",
journal = "Experimental and Clinical Endocrinology and Diabetes",
issn = "0947-7349",
publisher = "Johann Ambrosius Barth Verlag in Medizinverlage Heidelberg GmbH & Co. KG",
number = "10",

}

RIS

TY - JOUR

T1 - The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study

AU - Oskari Kilpeläinen, Tuomas

AU - Laaksonen, D E

AU - Lakka, T A

AU - Herder, C

AU - Koenig, W

AU - Lindström, J

AU - Eriksson, J G

AU - Uusitupa, M

AU - Kolb, H

AU - Laakso, M

AU - Tuomilehto, J

AU - Finnish Diabetes Prevention Study

N1 - © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

PY - 2010/11

Y1 - 2010/11

N2 - Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor ( TNF) gene and the rs1800795 SNP in the interleukin-6 ( IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels ( P = 0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL-6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.

AB - Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor ( TNF) gene and the rs1800795 SNP in the interleukin-6 ( IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels ( P = 0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL-6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.

KW - C-Reactive Protein

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Finland

KW - Genetic Association Studies

KW - Glucose Intolerance

KW - Humans

KW - Interleukin-6

KW - Male

KW - Motor Activity

KW - Overweight

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Time Factors

KW - Tumor Necrosis Factor-alpha

U2 - 10.1055/s-0030-1249686

DO - 10.1055/s-0030-1249686

M3 - Journal article

C2 - 20361391

VL - 118

SP - 757

EP - 759

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

IS - 10

ER -

ID: 46280175