Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. / Marabita, Francesco; James, Tojo; Karhu, Anu; Virtanen, Heidi; Kettunen, Kaisa; Stenlund, Hans; Boulund, Fredrik; Hellström, Cecilia; Neiman, Maja; Mills, Robert; Perheentupa, Teemu; Laivuori, Hannele; Helkkula, Pyry; Byrne, Myles; Jokinen, Ilkka; Honko, Harri; Kallonen, Antti; Ermes, Miikka; Similä, Heidi; Lindholm, Mikko; Widén, Elisabeth; Ripatti, Samuli; Perälä-Heape, Maritta; Engstrand, Lars; Nilsson, Peter; Moritz, Thomas; Miettinen, Timo; Sallinen, Riitta; Kallioniemi, Olli.

In: Cell Systems, Vol. 13, No. 3, 2022, p. 241-255.e7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Marabita, F, James, T, Karhu, A, Virtanen, H, Kettunen, K, Stenlund, H, Boulund, F, Hellström, C, Neiman, M, Mills, R, Perheentupa, T, Laivuori, H, Helkkula, P, Byrne, M, Jokinen, I, Honko, H, Kallonen, A, Ermes, M, Similä, H, Lindholm, M, Widén, E, Ripatti, S, Perälä-Heape, M, Engstrand, L, Nilsson, P, Moritz, T, Miettinen, T, Sallinen, R & Kallioniemi, O 2022, 'Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health', Cell Systems, vol. 13, no. 3, pp. 241-255.e7. https://doi.org/10.1016/j.cels.2021.11.001

APA

Marabita, F., James, T., Karhu, A., Virtanen, H., Kettunen, K., Stenlund, H., Boulund, F., Hellström, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes, M., Similä, H., ... Kallioniemi, O. (2022). Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. Cell Systems, 13(3), 241-255.e7. https://doi.org/10.1016/j.cels.2021.11.001

Vancouver

Marabita F, James T, Karhu A, Virtanen H, Kettunen K, Stenlund H et al. Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. Cell Systems. 2022;13(3):241-255.e7. https://doi.org/10.1016/j.cels.2021.11.001

Author

Marabita, Francesco ; James, Tojo ; Karhu, Anu ; Virtanen, Heidi ; Kettunen, Kaisa ; Stenlund, Hans ; Boulund, Fredrik ; Hellström, Cecilia ; Neiman, Maja ; Mills, Robert ; Perheentupa, Teemu ; Laivuori, Hannele ; Helkkula, Pyry ; Byrne, Myles ; Jokinen, Ilkka ; Honko, Harri ; Kallonen, Antti ; Ermes, Miikka ; Similä, Heidi ; Lindholm, Mikko ; Widén, Elisabeth ; Ripatti, Samuli ; Perälä-Heape, Maritta ; Engstrand, Lars ; Nilsson, Peter ; Moritz, Thomas ; Miettinen, Timo ; Sallinen, Riitta ; Kallioniemi, Olli. / Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. In: Cell Systems. 2022 ; Vol. 13, No. 3. pp. 241-255.e7.

Bibtex

@article{e8f86864ef9c4ebbae6f7297e303735c,
title = "Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health",
abstract = "We explored opportunities for personalized and predictive health care by collecting serial clinical measurements, health surveys, genomics, proteomics, autoantibodies, metabolomics, and gut microbiome data from 96 individuals who participated in a data-driven health coaching program over a 16-month period with continuous digital monitoring of activity and sleep. We generated a resource of >20,000 biological samples from this study and a compendium of >53 million primary data points for 558,032 distinct features. Multiomics factor analysis revealed distinct and independent molecular factors linked to obesity, diabetes, liver function, cardiovascular disease, inflammation, immunity, exercise, diet, and hormonal effects. For example, ethinyl estradiol, a common oral contraceptive, produced characteristic molecular and physiological effects, including increased levels of inflammation and impact on thyroid, cortisol levels, and pulse, that were distinct from other sources of variability observed in our study. In total, this work illustrates the value of combining deep molecular and digital monitoring of human health. A record of this paper's transparent peer review process is included in the supplemental information.",
keywords = "lifestyle changes, multiomics data integration, P4 medicine, personalized medicine, precision health, precision medicine, systems medicine",
author = "Francesco Marabita and Tojo James and Anu Karhu and Heidi Virtanen and Kaisa Kettunen and Hans Stenlund and Fredrik Boulund and Cecilia Hellstr{\"o}m and Maja Neiman and Robert Mills and Teemu Perheentupa and Hannele Laivuori and Pyry Helkkula and Myles Byrne and Ilkka Jokinen and Harri Honko and Antti Kallonen and Miikka Ermes and Heidi Simil{\"a} and Mikko Lindholm and Elisabeth Wid{\'e}n and Samuli Ripatti and Maritta Per{\"a}l{\"a}-Heape and Lars Engstrand and Peter Nilsson and Thomas Moritz and Timo Miettinen and Riitta Sallinen and Olli Kallioniemi",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2022",
doi = "10.1016/j.cels.2021.11.001",
language = "English",
volume = "13",
pages = "241--255.e7",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

AU - Marabita, Francesco

AU - James, Tojo

AU - Karhu, Anu

AU - Virtanen, Heidi

AU - Kettunen, Kaisa

AU - Stenlund, Hans

AU - Boulund, Fredrik

AU - Hellström, Cecilia

AU - Neiman, Maja

AU - Mills, Robert

AU - Perheentupa, Teemu

AU - Laivuori, Hannele

AU - Helkkula, Pyry

AU - Byrne, Myles

AU - Jokinen, Ilkka

AU - Honko, Harri

AU - Kallonen, Antti

AU - Ermes, Miikka

AU - Similä, Heidi

AU - Lindholm, Mikko

AU - Widén, Elisabeth

AU - Ripatti, Samuli

AU - Perälä-Heape, Maritta

AU - Engstrand, Lars

AU - Nilsson, Peter

AU - Moritz, Thomas

AU - Miettinen, Timo

AU - Sallinen, Riitta

AU - Kallioniemi, Olli

N1 - Publisher Copyright: © 2021

PY - 2022

Y1 - 2022

N2 - We explored opportunities for personalized and predictive health care by collecting serial clinical measurements, health surveys, genomics, proteomics, autoantibodies, metabolomics, and gut microbiome data from 96 individuals who participated in a data-driven health coaching program over a 16-month period with continuous digital monitoring of activity and sleep. We generated a resource of >20,000 biological samples from this study and a compendium of >53 million primary data points for 558,032 distinct features. Multiomics factor analysis revealed distinct and independent molecular factors linked to obesity, diabetes, liver function, cardiovascular disease, inflammation, immunity, exercise, diet, and hormonal effects. For example, ethinyl estradiol, a common oral contraceptive, produced characteristic molecular and physiological effects, including increased levels of inflammation and impact on thyroid, cortisol levels, and pulse, that were distinct from other sources of variability observed in our study. In total, this work illustrates the value of combining deep molecular and digital monitoring of human health. A record of this paper's transparent peer review process is included in the supplemental information.

AB - We explored opportunities for personalized and predictive health care by collecting serial clinical measurements, health surveys, genomics, proteomics, autoantibodies, metabolomics, and gut microbiome data from 96 individuals who participated in a data-driven health coaching program over a 16-month period with continuous digital monitoring of activity and sleep. We generated a resource of >20,000 biological samples from this study and a compendium of >53 million primary data points for 558,032 distinct features. Multiomics factor analysis revealed distinct and independent molecular factors linked to obesity, diabetes, liver function, cardiovascular disease, inflammation, immunity, exercise, diet, and hormonal effects. For example, ethinyl estradiol, a common oral contraceptive, produced characteristic molecular and physiological effects, including increased levels of inflammation and impact on thyroid, cortisol levels, and pulse, that were distinct from other sources of variability observed in our study. In total, this work illustrates the value of combining deep molecular and digital monitoring of human health. A record of this paper's transparent peer review process is included in the supplemental information.

KW - lifestyle changes

KW - multiomics data integration

KW - P4 medicine

KW - personalized medicine

KW - precision health

KW - precision medicine

KW - systems medicine

U2 - 10.1016/j.cels.2021.11.001

DO - 10.1016/j.cels.2021.11.001

M3 - Journal article

C2 - 34856119

AN - SCOPUS:85122964198

VL - 13

SP - 241-255.e7

JO - Cell Systems

JF - Cell Systems

SN - 2405-4712

IS - 3

ER -

ID: 290597115