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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. / Karlsson Linnér, Richard; Biroli, Pietro; Kong, Edward; Meddens, S Fleur W; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Maël; Tino, Stephen P; Abdellaoui, Abdel; Hammerschlag, Anke R; Nivard, Michel G; Okbay, Aysu; Rietveld, Cornelius A; Timshel, Pascal N.; Trzaskowski, Maciej; Vlaming, Ronald de; Zünd, Christian L; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H; Chen, Chia-Yen; Eibich, Peter; Fontanillas, Pierre; Gonzalez, Juan R; Joshi, Peter K; Karhunen, Ville; Kleinman, Aaron; Levin, Remy Z; Lill, Christina M; Meddens, Gerardus A; Muntané, Gerard; Sanchez-Roige, Sandra; Rooij, Frank J van; Taskesen, Erdogan; Wu, Yang; Zhang, Futao; Auton, Adam; Boardman, Jason D; Clark, David W; Conlin, Andrew; Dolan, Conor C; Fischbacher, Urs; Groenen, Patrick J F; Harris, Kathleen Mullan; Hasler, Gregor; Hofman, Albert; Ikram, Mohammad A; Jain, Sonia; Karlsson, Robert; Pers, Tune H.; 23and Me Research Team.
In:
Nature Genetics, Vol. 51, No. 2, 2019, p. 245-257.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Karlsson Linnér, R, Biroli, P, Kong, E, Meddens, SFW, Wedow, R, Fontana, MA, Lebreton, M, Tino, SP, Abdellaoui, A, Hammerschlag, AR, Nivard, MG, Okbay, A, Rietveld, CA, Timshel, PN, Trzaskowski, M, Vlaming, RD, Zünd, CL, Bao, Y, Buzdugan, L, Caplin, AH, Chen, C-Y, Eibich, P, Fontanillas, P, Gonzalez, JR, Joshi, PK, Karhunen, V, Kleinman, A, Levin, RZ, Lill, CM, Meddens, GA, Muntané, G, Sanchez-Roige, S, Rooij, FJV, Taskesen, E, Wu, Y, Zhang, F, Auton, A, Boardman, JD, Clark, DW, Conlin, A, Dolan, CC, Fischbacher, U, Groenen, PJF, Harris, KM, Hasler, G, Hofman, A, Ikram, MA, Jain, S, Karlsson, R
, Pers, TH & 23and Me Research Team 2019, '
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences',
Nature Genetics, vol. 51, no. 2, pp. 245-257.
https://doi.org/10.1038/s41588-018-0309-3APA
Karlsson Linnér, R., Biroli, P., Kong, E., Meddens, S. F. W., Wedow, R., Fontana, M. A., Lebreton, M., Tino, S. P., Abdellaoui, A., Hammerschlag, A. R., Nivard, M. G., Okbay, A., Rietveld, C. A., Timshel, P. N., Trzaskowski, M., Vlaming, R. D., Zünd, C. L., Bao, Y., Buzdugan, L., ... 23and Me Research Team (2019).
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
Nature Genetics,
51(2), 245-257.
https://doi.org/10.1038/s41588-018-0309-3Vancouver
Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA et al.
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
Nature Genetics. 2019;51(2):245-257.
https://doi.org/10.1038/s41588-018-0309-3Author
Karlsson Linnér, Richard ; Biroli, Pietro ; Kong, Edward ; Meddens, S Fleur W ; Wedow, Robbee ; Fontana, Mark Alan ; Lebreton, Maël ; Tino, Stephen P ; Abdellaoui, Abdel ; Hammerschlag, Anke R ; Nivard, Michel G ; Okbay, Aysu ; Rietveld, Cornelius A ; Timshel, Pascal N. ; Trzaskowski, Maciej ; Vlaming, Ronald de ; Zünd, Christian L ; Bao, Yanchun ; Buzdugan, Laura ; Caplin, Ann H ; Chen, Chia-Yen ; Eibich, Peter ; Fontanillas, Pierre ; Gonzalez, Juan R ; Joshi, Peter K ; Karhunen, Ville ; Kleinman, Aaron ; Levin, Remy Z ; Lill, Christina M ; Meddens, Gerardus A ; Muntané, Gerard ; Sanchez-Roige, Sandra ; Rooij, Frank J van ; Taskesen, Erdogan ; Wu, Yang ; Zhang, Futao ; Auton, Adam ; Boardman, Jason D ; Clark, David W ; Conlin, Andrew ; Dolan, Conor C ; Fischbacher, Urs ; Groenen, Patrick J F ; Harris, Kathleen Mullan ; Hasler, Gregor ; Hofman, Albert ; Ikram, Mohammad A ; Jain, Sonia ; Karlsson, Robert ; Pers, Tune H. ; 23and Me Research Team. / Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. In: Nature Genetics. 2019 ; Vol. 51, No. 2. pp. 245-257.
Bibtex
@article{ba701d1fe7b043019619365ae9e5898d,
title = "Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences",
abstract = "Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.",
author = "{Karlsson Linn{\'e}r}, Richard and Pietro Biroli and Edward Kong and Meddens, {S Fleur W} and Robbee Wedow and Fontana, {Mark Alan} and Ma{\"e}l Lebreton and Tino, {Stephen P} and Abdel Abdellaoui and Hammerschlag, {Anke R} and Nivard, {Michel G} and Aysu Okbay and Rietveld, {Cornelius A} and Timshel, {Pascal N.} and Maciej Trzaskowski and Vlaming, {Ronald de} and Z{\"u}nd, {Christian L} and Yanchun Bao and Laura Buzdugan and Caplin, {Ann H} and Chia-Yen Chen and Peter Eibich and Pierre Fontanillas and Gonzalez, {Juan R} and Joshi, {Peter K} and Ville Karhunen and Aaron Kleinman and Levin, {Remy Z} and Lill, {Christina M} and Meddens, {Gerardus A} and Gerard Muntan{\'e} and Sandra Sanchez-Roige and Rooij, {Frank J van} and Erdogan Taskesen and Yang Wu and Futao Zhang and Adam Auton and Boardman, {Jason D} and Clark, {David W} and Andrew Conlin and Dolan, {Conor C} and Urs Fischbacher and Groenen, {Patrick J F} and Harris, {Kathleen Mullan} and Gregor Hasler and Albert Hofman and Ikram, {Mohammad A} and Sonia Jain and Robert Karlsson and Pers, {Tune H.} and {23and Me Research Team}",
year = "2019",
doi = "10.1038/s41588-018-0309-3",
language = "English",
volume = "51",
pages = "245--257",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",
}
RIS
TY - JOUR
T1 - Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
AU - Karlsson Linnér, Richard
AU - Biroli, Pietro
AU - Kong, Edward
AU - Meddens, S Fleur W
AU - Wedow, Robbee
AU - Fontana, Mark Alan
AU - Lebreton, Maël
AU - Tino, Stephen P
AU - Abdellaoui, Abdel
AU - Hammerschlag, Anke R
AU - Nivard, Michel G
AU - Okbay, Aysu
AU - Rietveld, Cornelius A
AU - Timshel, Pascal N.
AU - Trzaskowski, Maciej
AU - Vlaming, Ronald de
AU - Zünd, Christian L
AU - Bao, Yanchun
AU - Buzdugan, Laura
AU - Caplin, Ann H
AU - Chen, Chia-Yen
AU - Eibich, Peter
AU - Fontanillas, Pierre
AU - Gonzalez, Juan R
AU - Joshi, Peter K
AU - Karhunen, Ville
AU - Kleinman, Aaron
AU - Levin, Remy Z
AU - Lill, Christina M
AU - Meddens, Gerardus A
AU - Muntané, Gerard
AU - Sanchez-Roige, Sandra
AU - Rooij, Frank J van
AU - Taskesen, Erdogan
AU - Wu, Yang
AU - Zhang, Futao
AU - Auton, Adam
AU - Boardman, Jason D
AU - Clark, David W
AU - Conlin, Andrew
AU - Dolan, Conor C
AU - Fischbacher, Urs
AU - Groenen, Patrick J F
AU - Harris, Kathleen Mullan
AU - Hasler, Gregor
AU - Hofman, Albert
AU - Ikram, Mohammad A
AU - Jain, Sonia
AU - Karlsson, Robert
AU - Pers, Tune H.
AU - 23and Me Research Team
PY - 2019
Y1 - 2019
N2 - Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
AB - Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
U2 - 10.1038/s41588-018-0309-3
DO - 10.1038/s41588-018-0309-3
M3 - Journal article
C2 - 30643258
VL - 51
SP - 245
EP - 257
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -
