Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

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Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. / Mauvais-Jarvis, Franck; Ueki, Kohjiro; Fruman, David A.; Hirshman, Michael F.; Sakamoto, Kei; Goodyear, Laurie J.; Iannacone, Matteo; Accili, Domenico; Cantley, Lewis C.; Ronald Kahn, C.

In: Journal of Clinical Investigation, Vol. 109, No. 1, 01.01.2002, p. 141-149.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mauvais-Jarvis, F, Ueki, K, Fruman, DA, Hirshman, MF, Sakamoto, K, Goodyear, LJ, Iannacone, M, Accili, D, Cantley, LC & Ronald Kahn, C 2002, 'Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes', Journal of Clinical Investigation, vol. 109, no. 1, pp. 141-149. https://doi.org/10.1172/JCI0213305

APA

Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., & Ronald Kahn, C. (2002). Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation, 109(1), 141-149. https://doi.org/10.1172/JCI0213305

Vancouver

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ et al. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation. 2002 Jan 1;109(1):141-149. https://doi.org/10.1172/JCI0213305

Author

Mauvais-Jarvis, Franck ; Ueki, Kohjiro ; Fruman, David A. ; Hirshman, Michael F. ; Sakamoto, Kei ; Goodyear, Laurie J. ; Iannacone, Matteo ; Accili, Domenico ; Cantley, Lewis C. ; Ronald Kahn, C. / Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. In: Journal of Clinical Investigation. 2002 ; Vol. 109, No. 1. pp. 141-149.

Bibtex

@article{0ba382701dfb4b20b99c877ac4c08d70,
title = "Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes",
abstract = "A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3-kinase, p85α and its splice variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 improves insulin signaling and glucose homeostasis in normal mice and mice made insulin-resistant by heterozygous deletion of the Insulin receptor and/or insulin receptor substrate-1 (IRS1) genes. Reduced expression of p85 modulates the molecular balance between this protein, the p110 catalytic subunit of PI 3-kinase, and the IRS proteins. Thus, despite the decrease in p85α, PI 3-kinase activation is normal, insulin-stimulated Akt activity is increased, and glucose tolerance and insulin sensitivity are improved. Furthermore, Pik3r1 heterozygosity protects mice with genetic insulin resistance from developing diabetes. These data suggest that regulation of p85α levels may provide a novel therapeutic target for the treatment of type 2 diabetes.",
author = "Franck Mauvais-Jarvis and Kohjiro Ueki and Fruman, {David A.} and Hirshman, {Michael F.} and Kei Sakamoto and Goodyear, {Laurie J.} and Matteo Iannacone and Domenico Accili and Cantley, {Lewis C.} and {Ronald Kahn}, C.",
year = "2002",
month = jan,
day = "1",
doi = "10.1172/JCI0213305",
language = "English",
volume = "109",
pages = "141--149",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "1",

}

RIS

TY - JOUR

T1 - Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

AU - Mauvais-Jarvis, Franck

AU - Ueki, Kohjiro

AU - Fruman, David A.

AU - Hirshman, Michael F.

AU - Sakamoto, Kei

AU - Goodyear, Laurie J.

AU - Iannacone, Matteo

AU - Accili, Domenico

AU - Cantley, Lewis C.

AU - Ronald Kahn, C.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3-kinase, p85α and its splice variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 improves insulin signaling and glucose homeostasis in normal mice and mice made insulin-resistant by heterozygous deletion of the Insulin receptor and/or insulin receptor substrate-1 (IRS1) genes. Reduced expression of p85 modulates the molecular balance between this protein, the p110 catalytic subunit of PI 3-kinase, and the IRS proteins. Thus, despite the decrease in p85α, PI 3-kinase activation is normal, insulin-stimulated Akt activity is increased, and glucose tolerance and insulin sensitivity are improved. Furthermore, Pik3r1 heterozygosity protects mice with genetic insulin resistance from developing diabetes. These data suggest that regulation of p85α levels may provide a novel therapeutic target for the treatment of type 2 diabetes.

AB - A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3-kinase, p85α and its splice variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 improves insulin signaling and glucose homeostasis in normal mice and mice made insulin-resistant by heterozygous deletion of the Insulin receptor and/or insulin receptor substrate-1 (IRS1) genes. Reduced expression of p85 modulates the molecular balance between this protein, the p110 catalytic subunit of PI 3-kinase, and the IRS proteins. Thus, despite the decrease in p85α, PI 3-kinase activation is normal, insulin-stimulated Akt activity is increased, and glucose tolerance and insulin sensitivity are improved. Furthermore, Pik3r1 heterozygosity protects mice with genetic insulin resistance from developing diabetes. These data suggest that regulation of p85α levels may provide a novel therapeutic target for the treatment of type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0036142957&partnerID=8YFLogxK

U2 - 10.1172/JCI0213305

DO - 10.1172/JCI0213305

M3 - Journal article

C2 - 11781359

AN - SCOPUS:0036142957

VL - 109

SP - 141

EP - 149

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 1

ER -

ID: 239778374