The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

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The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles. / Sakuma, Kunihiro; Watanabe, Kimi; Sano, Mamoru; Uramoto, Isao; Sakamoto, Kei; Totsuka, Tsuyoshi.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1428, No. 2-3, 05.08.1999, p. 284-292.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sakuma, K, Watanabe, K, Sano, M, Uramoto, I, Sakamoto, K & Totsuka, T 1999, 'The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles', Biochimica et Biophysica Acta - General Subjects, vol. 1428, no. 2-3, pp. 284-292. https://doi.org/10.1016/S0304-4165(99)00086-0

APA

Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, K., & Totsuka, T. (1999). The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles. Biochimica et Biophysica Acta - General Subjects, 1428(2-3), 284-292. https://doi.org/10.1016/S0304-4165(99)00086-0

Vancouver

Sakuma K, Watanabe K, Sano M, Uramoto I, Sakamoto K, Totsuka T. The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles. Biochimica et Biophysica Acta - General Subjects. 1999 Aug 5;1428(2-3):284-292. https://doi.org/10.1016/S0304-4165(99)00086-0

Author

Sakuma, Kunihiro ; Watanabe, Kimi ; Sano, Mamoru ; Uramoto, Isao ; Sakamoto, Kei ; Totsuka, Tsuyoshi. / The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles. In: Biochimica et Biophysica Acta - General Subjects. 1999 ; Vol. 1428, No. 2-3. pp. 284-292.

Bibtex

@article{cc84888323194268be527cd91622aff5,
title = "The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles",
abstract = "Using Western blot analysis, we investigated whether the amount of myogenic regulatory factors differs in slow-type and fast-type muscles. In addition, we examined the adaptive response of myogenic regulatory factor protein in the overloaded rat muscles by the ablation of synergists, in the regenerating muscles following bupivacaine injection and in the denervated muscle. The amount of myogenin protein in the slow-type muscle was markedly greater. In contrast, the proteins MyoD and Myf-5 were selectively accumulated in the fast-type muscles. A gradual down-regulation of MyoD and Myf-5 proteins was detected in the denervated fast-type muscles, but not in the myogenin protein content. A rapid down-regulation of myogenic regulatory factor protein was observed both of the mechanically overloaded and in the regenerating muscles. These results indicate that the fast-type-specific gene expression in muscle is modulated by MyoD and Myf-5 proteins and suggest that myogenin protein plays an important role in the reconstruction of damaged neuromuscular connections. Copyright (C) 1999 Elsevier Science B.V.",
keywords = "Motor denervation, Muscle hypertrophy, Muscle regeneration, Myogenic regulatory factor",
author = "Kunihiro Sakuma and Kimi Watanabe and Mamoru Sano and Isao Uramoto and Kei Sakamoto and Tsuyoshi Totsuka",
year = "1999",
month = aug,
day = "5",
doi = "10.1016/S0304-4165(99)00086-0",
language = "English",
volume = "1428",
pages = "284--292",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "2-3",

}

RIS

TY - JOUR

T1 - The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

AU - Sakuma, Kunihiro

AU - Watanabe, Kimi

AU - Sano, Mamoru

AU - Uramoto, Isao

AU - Sakamoto, Kei

AU - Totsuka, Tsuyoshi

PY - 1999/8/5

Y1 - 1999/8/5

N2 - Using Western blot analysis, we investigated whether the amount of myogenic regulatory factors differs in slow-type and fast-type muscles. In addition, we examined the adaptive response of myogenic regulatory factor protein in the overloaded rat muscles by the ablation of synergists, in the regenerating muscles following bupivacaine injection and in the denervated muscle. The amount of myogenin protein in the slow-type muscle was markedly greater. In contrast, the proteins MyoD and Myf-5 were selectively accumulated in the fast-type muscles. A gradual down-regulation of MyoD and Myf-5 proteins was detected in the denervated fast-type muscles, but not in the myogenin protein content. A rapid down-regulation of myogenic regulatory factor protein was observed both of the mechanically overloaded and in the regenerating muscles. These results indicate that the fast-type-specific gene expression in muscle is modulated by MyoD and Myf-5 proteins and suggest that myogenin protein plays an important role in the reconstruction of damaged neuromuscular connections. Copyright (C) 1999 Elsevier Science B.V.

AB - Using Western blot analysis, we investigated whether the amount of myogenic regulatory factors differs in slow-type and fast-type muscles. In addition, we examined the adaptive response of myogenic regulatory factor protein in the overloaded rat muscles by the ablation of synergists, in the regenerating muscles following bupivacaine injection and in the denervated muscle. The amount of myogenin protein in the slow-type muscle was markedly greater. In contrast, the proteins MyoD and Myf-5 were selectively accumulated in the fast-type muscles. A gradual down-regulation of MyoD and Myf-5 proteins was detected in the denervated fast-type muscles, but not in the myogenin protein content. A rapid down-regulation of myogenic regulatory factor protein was observed both of the mechanically overloaded and in the regenerating muscles. These results indicate that the fast-type-specific gene expression in muscle is modulated by MyoD and Myf-5 proteins and suggest that myogenin protein plays an important role in the reconstruction of damaged neuromuscular connections. Copyright (C) 1999 Elsevier Science B.V.

KW - Motor denervation

KW - Muscle hypertrophy

KW - Muscle regeneration

KW - Myogenic regulatory factor

UR - http://www.scopus.com/inward/record.url?scp=0032781215&partnerID=8YFLogxK

U2 - 10.1016/S0304-4165(99)00086-0

DO - 10.1016/S0304-4165(99)00086-0

M3 - Journal article

C2 - 10434046

AN - SCOPUS:0032781215

VL - 1428

SP - 284

EP - 292

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 2-3

ER -

ID: 239779514