The Salt-Inducible Kinases: Emerging Metabolic Regulators

Research output: Contribution to journal › Review › Research › peer-review

Standard

The Salt-Inducible Kinases : Emerging Metabolic Regulators. / Sakamoto, Kei; Bultot, Laurent; Göransson, Olga.

In: Trends in Endocrinology and Metabolism, Vol. 29, No. 12, 12.2018, p. 827-840.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Sakamoto, K, Bultot, L & Göransson, O 2018, 'The Salt-Inducible Kinases: Emerging Metabolic Regulators', Trends in Endocrinology and Metabolism, vol. 29, no. 12, pp. 827-840. https://doi.org/10.1016/j.tem.2018.09.007

APA

Sakamoto, K., Bultot, L., & Göransson, O. (2018). The Salt-Inducible Kinases: Emerging Metabolic Regulators. Trends in Endocrinology and Metabolism, 29(12), 827-840. https://doi.org/10.1016/j.tem.2018.09.007

Vancouver

Sakamoto K, Bultot L, Göransson O. The Salt-Inducible Kinases: Emerging Metabolic Regulators. Trends in Endocrinology and Metabolism. 2018 Dec;29(12):827-840. https://doi.org/10.1016/j.tem.2018.09.007

Author

Sakamoto, Kei ; Bultot, Laurent ; Göransson, Olga. / The Salt-Inducible Kinases : Emerging Metabolic Regulators. In: Trends in Endocrinology and Metabolism. 2018 ; Vol. 29, No. 12. pp. 827-840.

Bibtex

@article{7b8869c7e4514171b34092f7f823c1ea,
title = "The Salt-Inducible Kinases: Emerging Metabolic Regulators",
abstract = "The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.",
keywords = "AMP-activated protein kinase, AMPK, AMPK-related kinase, energy metabolism, gluconeogenesis, LKB1",
author = "Kei Sakamoto and Laurent Bultot and Olga G{\"o}ransson",
year = "2018",
month = dec,
doi = "10.1016/j.tem.2018.09.007",
language = "English",
volume = "29",
pages = "827--840",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "12",

}

RIS

TY - JOUR

T1 - The Salt-Inducible Kinases

T2 - Emerging Metabolic Regulators

AU - Sakamoto, Kei

AU - Bultot, Laurent

AU - Göransson, Olga

PY - 2018/12

Y1 - 2018/12

N2 - The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.

AB - The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.

KW - AMP-activated protein kinase

KW - AMPK

KW - AMPK-related kinase

KW - energy metabolism

KW - gluconeogenesis

KW - LKB1

UR - http://www.scopus.com/inward/record.url?scp=85055532936&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2018.09.007

DO - 10.1016/j.tem.2018.09.007

M3 - Review

C2 - 30385008

AN - SCOPUS:85055532936

VL - 29

SP - 827

EP - 840

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 12

ER -

ID: 238433124