Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle
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Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. / Kristensen, Jonas Møller; Treebak, Jonas Thue; Schjerling, Peter; Goodyear, Laurie; Wojtaszewski, Jorgen F P; Wojtaszewski, Jørgen.
In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 306, No. 10, 2014, p. E1099-E1109.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle
AU - Kristensen, Jonas Møller
AU - Treebak, Jonas Thue
AU - Schjerling, Peter
AU - Goodyear, Laurie
AU - Wojtaszewski, Jorgen F P
AU - Wojtaszewski, Jørgen
N1 - CURSI 2014 NEXS 096
PY - 2014
Y1 - 2014
N2 - Background: Metformin-induced activation of AMPK has been associated with enhanced glucose uptake in skeletal muscle but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles is dependent upon AMPK signaling. Methods: Oral doses of metformin or saline treatment were given muscle-specific kinase α2 dead AMPK mice (KD) and wild type (WT) littermates either once or chronically for 2 weeks. Soleus and Extensor Digitorum Longus (EDL) muscles were used for measurements of glucose transport and Western blot analyzes. Results: Chronic treatment with metformin enhanced insulin-stimulated glucose uptake in soleus muscles of WT (45%, P
AB - Background: Metformin-induced activation of AMPK has been associated with enhanced glucose uptake in skeletal muscle but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles is dependent upon AMPK signaling. Methods: Oral doses of metformin or saline treatment were given muscle-specific kinase α2 dead AMPK mice (KD) and wild type (WT) littermates either once or chronically for 2 weeks. Soleus and Extensor Digitorum Longus (EDL) muscles were used for measurements of glucose transport and Western blot analyzes. Results: Chronic treatment with metformin enhanced insulin-stimulated glucose uptake in soleus muscles of WT (45%, P
U2 - 10.1152/ajpendo.00417.2013
DO - 10.1152/ajpendo.00417.2013
M3 - Journal article
C2 - 24644243
VL - 306
SP - E1099-E1109
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 10
ER -
ID: 105487526