Metabolic Signaling in the Sakamoto Group

The Sakamoto Group investigates fundamental molecular signaling mechanisms that control energy metabolism and glucose homeostasis associated with exercise, insulin resistance and type 2 diabetes.

Researcher working in a lab

 

 

 

 

 

 

 

 

Every human cell is governed by highly complex networks of signaling molecules that work together to regulate cellular functions and maintain organismal homeostasis. Majority of the key metabolic enzymes are specifically and coordinately regulated through interplay between allosteric and covalent post-translational modification (e.g. phosphorylation) regulations in response to changes in the levels of various factors, including hormones/cytokines, nutrients, and metabolites. Elucidating the molecular control and physiological role of such interplay is critical to understand complex metabolic processes and for discovery of potential new therapies.

A major strength of the group is that we established a robust and unique approach, consisting of structure-guided mutagenesis, detailed enzyme kinetics of the mutant proteins, and comprehensive in vivo metabolic analyses. This has enabled us for example to reveal the key role that an allosteric activator of glucose metabolite (glucose 6-phosphate) plays in regulating insulin-stimulated glycogen synthesis in vivo in skeletal muscle and liver.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CBMR Voices

CBMR Voices Logo

Get a deeper insight into life and work at the Center in our blog CBMR Voices. Below are links to interviews with some of the Sakamoto Group members:

Faces of CBMR: Postdoc Florentina Negoita

Faces of CBMR: Visiting Student Pamina Gräsle

Faces of CBMR: Postdoc Fiona Louise Roberts

Faces of CBMR: Postdoc Greg Robert Markby

Faces of CBMR: Staff Scientist Danial Ahwazi

Group Leader, Professor Kei Sakamoto

Group Leader

Kei Sakamoto
Professor

Phone +45 35 33 40 07
kei.sakamoto@sund.ku.dk

Twitter: @kei_sakamoto

Linkedin: Kei Sakamoto at CBMR

Group members

Name Title Job responsibilities Image
Ahwazi, Danial PhD Student Sakamoto Group, Metabolic Signaling Billede af Ahwazi, Danial
Biswas, Dipsikha Postdoc Sakamoto Group, Metabolic Signalling Billede af Biswas, Dipsikha
Hellberg, Anna Kristina Staff Scientist Sakamoto Group, Metabolic Signaling Billede af Hellberg, Anna Kristina
Holgersen Bryde, Tenna Research Assistant Sakamoto Group, Metabolic Signaling Billede af Holgersen Bryde, Tenna
Jensen, Marianne Agerholm Staff Scientist Sakamoto Group, Metabolic Signaling Billede af Jensen, Marianne Agerholm
Luda, Katarzyna Maria Postdoc Sakamoto Group, Metabolic Signalling Billede af Luda, Katarzyna Maria
Markby, Greg Robert Postdoc Sakamoto Group, Metabolic Signaling Billede af Markby, Greg Robert
Negoita, Ionela Florentina Postdoc Sakamoto Group, Metabolic Signaling Billede af Negoita, Ionela Florentina
Pradas Juni, Marta Staff Scientist Sakamoto Group, Metabolic Signaling Billede af Pradas Juni, Marta
Roberts, Fiona Louise Postdoc Sakamoto Group, Metabolic Signaling Billede af Roberts, Fiona Louise
Sakamoto, Kei Professor Vice Executive Director, Group Leader, Sakamoto Group, Metabolic Signaling Billede af Sakamoto, Kei

External Researchers

Name Title Telefon E-mail
Tran Phan Postdoc International Alliance Postdoc (based in Dundee) Portrait of Postdoc Tran Phan

Photo of staff in the Sakamoto Group

From the left: Danial Ahwazi, Kei Sakamoto, Pamina Gräsle, Greg Robert Markby and Fiona Louise Roberts.