Novo Nordisk Foundation
Center for Basic Metabolic Research

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Scientists dive deep into the different effects of morning and evening exercise

Exercise causes the body to release different signals that improve health and now scientists have mapped these signals and how they are released in mice.

Research in Molecular Metabolism

Mice with low NAD+ levels die young – and scientists now know why

With low levels of the molecule NAD+, skeletal muscle cells are unable to control the concentration of calcium ions, which causes mitochondria in the cells to burst and the skeletal muscle cell to collapse.

Brain cells that regulate whole-body metabolism and energy intake die without a key enzyme

Imbalances in levels of the enzyme MAPT could affect our ability to regulate our energy needs, and play a role in the development of obesity and type 2 diabetes.

How muscles and fat cells work together to make you more fit

Short-term exercise training increases levels of the enzyme DICER in fat cells. DICER in fat helps muscles adapt to exercise and increase performance.

Exercise may have different effects in the Morning and Evening

The effect of exercise may differ depending on the time of day it is performed. In mice they demonstrate that exercise in the morning results in an increased metabolic response in skeletal muscle.